May 6, 2026 · Glossary
50 Must-Know Chemistry Terms (with Examples)
Chemistry has its own vocabulary, and most of it shows up in the first chapter of every textbook before it ever gets a clear definition. Here are the 50 terms you actually need to read a chemistry textbook — every one with a plain-English definition and a real example.
Atomic structure
- Atom
- The smallest unit of an element that retains the element's properties.
- Proton
- Positively charged particle in the nucleus.
- Neutron
- Neutral particle in the nucleus, similar mass to a proton.
- Electron
- Negatively charged particle that orbits the nucleus.
- Atomic number
- The number of protons in an atom's nucleus.
- Mass number
- Total number of protons plus neutrons.
- Isotope
- Atoms of the same element with different numbers of neutrons.
- Ion
- An atom that has gained or lost electrons, giving it an electric charge.
- Cation
- A positively charged ion (lost electrons).
- Anion
- A negatively charged ion (gained electrons).
e.g. A single gold atom is still gold; you can't divide it further with chemistry.
e.g. Carbon has 6 protons. Always. That's what makes it carbon.
e.g. Carbon-12 has 6 neutrons. Carbon-14 has 8 — same element, different isotope.
e.g. Hydrogen has 1 electron. Sodium has 11. Electrons drive almost all chemistry.
e.g. Iron has atomic number 26 — meaning 26 protons.
e.g. Carbon-14 has a mass number of 14 (6 protons + 8 neutrons).
e.g. Hydrogen, deuterium, and tritium are all isotopes of hydrogen.
e.g. Sodium losing one electron becomes Na⁺. Chlorine gaining one becomes Cl⁻.
e.g. Ca²⁺ in bones, K⁺ in your nerves.
e.g. Cl⁻ in salt, OH⁻ in soap.
The periodic table
- Element
- A pure substance made of only one type of atom.
- Group
- A column on the periodic table; elements share chemical behavior.
- Period
- A row on the periodic table; elements have the same number of electron shells.
- Metal
- Conducts electricity, malleable, usually shiny — most of the table.
- Nonmetal
- Brittle, doesn't conduct, found on the right side of the table.
- Metalloid
- An element with properties between metal and nonmetal.
- Halogen
- Group 17 element — extremely reactive nonmetals.
- Noble gas
- Group 18 element — almost completely unreactive.
- Transition metal
- Groups 3–12; can have multiple oxidation states.
- Lanthanide
- First f-block row; rare-earth elements (atomic numbers 57–71).
e.g. Iron, oxygen, gold, neon — all elements.
e.g. Group 1 = alkali metals. Group 18 = noble gases.
e.g. Period 2 has 8 elements. Period 6 has 32.
e.g. Iron, copper, gold, sodium, mercury are all metals.
e.g. Oxygen, nitrogen, sulfur, chlorine — all nonmetals.
e.g. Silicon makes up computer chips because it's a semiconductor.
e.g. Chlorine in pools. Fluorine in toothpaste. Iodine in salt.
e.g. Helium balloons, neon signs, argon in incandescent bulbs.
e.g. Iron, copper, silver, gold all live here.
e.g. Neodymium magnets in your headphones, europium in TV phosphors.
Chemical bonding
- Chemical bond
- An attractive force that holds atoms together.
- Ionic bond
- Bond formed when one atom gives an electron to another.
- Covalent bond
- Bond formed when two atoms share electrons.
- Polar covalent bond
- A covalent bond where electrons are shared unequally.
- Electronegativity
- How strongly an atom attracts electrons in a bond.
- Molecule
- Two or more atoms covalently bonded together.
- Compound
- A substance made of two or more different elements bonded together.
- Lewis structure
- A diagram showing valence electrons and bonds.
- Valence electron
- An electron in the outermost shell — what bonds form with.
- Octet rule
- Atoms tend to bond until they have 8 valence electrons.
e.g. The bond between H and O in water is what makes water a single molecule.
e.g. Na⁺ and Cl⁻ in table salt are held together by electrostatic attraction.
e.g. The two H–O bonds in water are covalent.
e.g. In water, oxygen pulls harder on the shared electrons than hydrogen does.
e.g. Fluorine has the highest electronegativity (3.98). Cesium has one of the lowest (0.79).
e.g. H₂O, CO₂, O₂ — all molecules.
e.g. Water (H₂O) is a compound. Pure oxygen (O₂) is not.
e.g. The water Lewis structure has 2 lone pairs on oxygen and 2 bonds to hydrogen.
e.g. Carbon has 4 valence electrons, so it forms 4 bonds.
e.g. Oxygen needs 2 more electrons to reach 8 — that's why H₂O exists.
Reactions and stoichiometry
- Chemical reaction
- A process that converts one set of substances into another.
- Reactant
- A starting substance in a reaction.
- Product
- A substance produced by a reaction.
- Coefficient
- Number in front of a formula in a chemical equation.
- Balanced equation
- An equation with equal atoms of each element on both sides.
- Mole
- A unit equal to 6.022 × 10²³ particles (Avogadro's number).
- Molar mass
- Mass of one mole of a substance, in grams.
- Stoichiometry
- The math of reactant and product quantities in a reaction.
- Limiting reagent
- The reactant that runs out first and limits product.
- Catalyst
- A substance that speeds up a reaction without being consumed.
e.g. 2H₂ + O₂ → 2H₂O is a reaction (combustion of hydrogen).
e.g. In burning wood, the wood and the oxygen in the air are reactants.
e.g. Burning wood produces CO₂ and water vapor as products.
e.g. In 2H₂ + O₂ → 2H₂O, the coefficient on H₂O is 2.
e.g. Conservation of mass — atoms aren't created or destroyed.
e.g. 1 mole of carbon weighs 12 grams.
e.g. Water has a molar mass of 18 g/mol (2 × 1 + 16).
e.g. If you have 2 moles of H₂, you need 1 mole of O₂ to make 2 moles of water.
e.g. If you have 5 buns and 10 burgers, buns are the limiting reagent.
e.g. Platinum catalyzes the reactions in your car's catalytic converter.
States of matter and solutions
- Solid
- Matter with a fixed shape and volume.
- Liquid
- Matter with fixed volume but no fixed shape.
- Gas
- Matter with no fixed shape or volume.
- Plasma
- Ionized gas — a fourth state of matter.
- Solution
- A homogeneous mixture of two or more substances.
- Solute
- The substance dissolved.
- Solvent
- The substance doing the dissolving.
- Concentration
- How much solute is in a given amount of solvent.
- pH
- A measure of how acidic or basic a solution is (0 = strong acid, 14 = strong base).
- Acid
- A substance that donates H⁺ ions in solution.
e.g. Ice, iron, salt.
e.g. Water, mercury, ethanol.
e.g. Oxygen, nitrogen, helium.
e.g. Lightning, the Sun, neon signs.
e.g. Salt water, brass, air.
e.g. In salt water, salt is the solute.
e.g. In salt water, water is the solvent.
e.g. Seawater is about 3.5% salt by mass.
e.g. Pure water has a pH of 7. Lemon juice is around 2.
e.g. HCl, vinegar (acetic acid), citric acid.
Apply it
Practice in The Lab
See these terms in action with the interactive periodic table and chemistry trivia games.
Open The Lab →Frequently asked questions
Which chemistry terms should I memorize first?
Start with the atomic structure terms — atom, proton, neutron, electron, isotope, ion. These are the building blocks for everything else. Then move to chemical bonding (ionic, covalent, electronegativity), then to reactions (mole, balanced equation, stoichiometry). Memorizing them in this order builds understanding instead of just facts.
What's the difference between a molecule and a compound?
All compounds are molecules, but not all molecules are compounds. A molecule is two or more atoms bonded together — they can be the same element (O₂ is a molecule of two oxygen atoms) or different. A compound specifically requires two or more different elements (H₂O is a compound; O₂ is not).
Do I need to know all these for the SAT or AP Chemistry?
Yes, and quite a few more. The terms here cover the foundational vocabulary for high-school chemistry, AP Chemistry, and the SAT II Chemistry Subject Test. AP Chem expects fluency with all 50 of these plus thermochemistry terms (enthalpy, entropy), kinetics terms (rate law, activation energy), and equilibrium terms (Le Chatelier's principle, Keq).
Which standards does this vocabulary cover?
These terms are the language of NGSS HS-PS1 (Matter and Its Interactions). Specifically, HS-PS1-1 (use the periodic table to predict properties), HS-PS1-2 (chemical reactions at the bulk scale), HS-PS1-3 (intermolecular forces), and HS-PS1-7 (mass conservation in reactions). The vocabulary also supports CCSS.ELA-LITERACY.RST.9-10.4 (technical word recognition).